Click on a game below to view boxscore.
| Date | Opponent | Score | R H E | R H E | Inns | Overall | ACC | Pitcher of Record | Attend | Time | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| February 11, 2022 |  vs Wisconsin | W | 5-4 | 5 7 3 | 4 1 2 | 7 | 1-0 | - | Emma Lemley (W 0-0) | 0 | |
| February 11, 2022 |  vs Northwestern | W | 3-2 | 3 6 1 | 2 3 1 | 7 | 2-0 | - | Keely Rochard (W 1-0) | 0 | 2:05 |
| February 12, 2022 |  vs Michigan State | W | 5-1 | 5 11 0 | 1 4 1 | 7 | 3-0 | - | Emma Lemley (W 2-0) | 0 | 2:12 |
| February 12, 2022 |  vs (11) Missouri | W | 4-3 | 4 9 1 | 3 6 2 | 7 | 4-0 | - | Keely Rochard (W 2-0) | 0 | 2:20 |
| February 13, 2022 |  vs (19) Kentucky | W | 6-1 | 6 6 0 | 1 4 1 | 7 | 5-0 | - | Keely Rochard (W 2-0) | 150 | 3:30pm |
| February 18, 2022 |  at (2) Alabama | L | 0-1 | 0 3 1 | 1 2 0 | 7 | 5-1 | - | Keely Rochard (L 3-1) | 0 | 1:58 |
| February 18, 2022 |  vs Middle Tennessee | W | 3-2 | 3 5 1 | 2 4 1 | 7 | 6-1 | - | Emma Lemley (W 3-0) | 0 | 1:53 |
| February 19, 2022 | at (2) Alabama | L | 0-2 | 0 9 1 | 2 5 0 | 7 | 6-2 | - | Emma Lemley (L 3-1) | 3940 | 1:59 |
| February 19, 2022 |  vs Evansville | W | 5-1 | 5 5 0 | 1 3 0 | 7 | 7-2 | - | Keely Rochard (W 4-1) | 0 | 1:33 |
| February 20, 2022 | vs Evansville | W | 5-0 | 5 7 0 | 0 2 3 | 7 | 8-2 | - | Emma Lemley (W 4-1) | 0 | 1:26 |
| February 25, 2022 |  vs Ohio State | W | 1-0 | 1 4 0 | 0 3 1 | (9) | 9-2 | - | Keely Rochard (W 5-1) | 214 | 2:07 |
| February 26, 2022 |  vs Miami University | W | 8-0 | 8 11 1 | 0 4 2 | (5) | 10-2 | - | Emma Lemley (W 5-1) | 212 | 1:34 |
| February 26, 2022 |  at South Carolina | W | 5-3 | 5 7 1 | 3 2 1 | 7 | 11-2 | - | Keely Rochard (W 6-1) | 1752 | 2:26 |
| March 2, 2022 |  at Charlotte | L | 2-5 | 2 9 1 | 5 6 2 | 7 | 11-3 | - | Keely Rochard (L 6-2) | 207 | 2hrs |
| March 4, 2022 |  at (14) Clemson * | W | 6-1 | 6 11 1 | 1 4 0 | 7 | 12-3 | 1-0 | Keely Rochard (W 7-2) | 1616 | 2:38 |
| March 5, 2022 | at (14) Clemson * | W | 4-0 | 4 11 1 | 0 3 4 | 7 | 13-3 | 2-0 | Emma Lemley (W 6-1) | 1616 | 2:15 |
| March 6, 2022 | at (14) Clemson * | W | 4-2 | 4 7 2 | 2 5 2 | 7 | 14-3 | 3-0 | Keely Rochard (W 8-2) | 1616 | 2:35 |
| March 9, 2022 |  EAST TENNESSEE STATE | W | 18-2 | 18 17 0 | 2 2 3 | (5) | 15-3 | - | Mackenzie Osborne (W 1-0) | 212 | 2:03 |
| March 11, 2022 |  SYRACUSE * | W | 13-1 | 13 12 0 | 1 3 0 | (5) | 16-3 | 4-0 | Keely Rochard (W 9-2) | 319 | 1:54 |
| March 11, 2022 | SYRACUSE * | W | 8-1 | 8 10 1 | 1 4 1 | 7 | 17-3 | 5-0 | Emma Lemley (W 7-1) | 273 | 2:13 |
| March 13, 2022 | SYRACUSE * | W | 6-1 | 6 8 0 | 1 3 1 | 7 | 18-3 | 6-0 | Keely Rochard (W 10-2) | 210 | 2:00 |
| March 18, 2022 |  NORTH CAROLINA * | W | 10-0 | 10 9 0 | 0 2 0 | (5) | 19-3 | 7-0 | Keely Rochard (W 11-2) | 285 | 1:46 |
| March 19, 2022 | NORTH CAROLINA * | W | 8-5 | 8 12 0 | 5 6 1 | 7 | 20-3 | 8-0 | Emma Lemley (W 8-1) | 825 | 2:32 |
| March 20, 2022 | NORTH CAROLINA * | W | 9-1 | 9 10 0 | 1 2 1 | (5) | 21-3 | 9-0 | Keely Rochard (W 12-2) | 475 | 1:39 |
| March 22, 2022 |  at Longwood | W | 5-0 | 5 7 1 | 0 0 2 | 7 | 22-3 | - | Emma Lemley (W 9-1) | 0 | 146 |
| March 22, 2022 | at Longwood | W | 13-0 | 13 15 1 | 0 0 2 | (5) | 23-3 | - | Ivy Rosenberry (W 1-0) | 493 | 1:49 |
| March 25, 2022 |  at Pitt * | W | 12-3 | 12 10 0 | 3 6 2 | (5) | 24-3 | 10-0 | Keely Rochard (W 13-2) | 35 | 1:55 |
| March 25, 2022 | at Pitt * | W | 7-2 | 7 10 1 | 2 4 2 | 7 | 25-3 | 11-0 | Emma Lemley (W 10-1) | 150 | 1:47 |
| April 3, 2022 |  at (22) UCF | W | 1-0 | 1 2 0 | 0 0 2 | 7 | 26-3 | - | Keely Rochard (W 14-2) | 953 | 1:47 |
| April 3, 2022 | at (22) UCF | W | 7-0 | 7 13 1 | 0 1 3 | 7 | 27-3 | - | Emma Lemley (W 11-1) | 953 | 2:18 |
| April 4, 2022 | at (22) UCF | L | 4-5 | 4 12 0 | 5 9 0 | (11) | 27-4 | - | Emma Lemley (L 11-2) | 448 | 3:18 |
| April 8, 2022 |  at (3) Florida State * | W | 6-3 | 6 6 2 | 3 5 1 | (9) | 28-4 | 12-0 | Keely Rochard (W 15-2) | 1403 | 2:56 |
| April 9, 2022 | at (3) Florida State * | W | 23-9 | 23 21 1 | 9 6 5 | 7 | 29-4 | 13-0 | Keely Rochard (W 16-2) | 1731 | 3:12 |
| April 10, 2022 | at (3) Florida State * | L | 6-8 | 6 7 1 | 8 8 0 | 7 | 29-5 | 13-1 | Emma Lemley (L 11-3) | 1262 | 2:20 |
| April 12, 2022 |  at Liberty | W | 8-1 | 8 13 0 | 1 3 0 | 7 | 30-5 | - | Emma Lemley (W 12-3) | 1114 | 2:43 |
| April 14, 2022 |  VIRGINIA * | W | 5-1 | 5 10 0 | 1 3 1 | 7 | 31-5 | 14-1 | Keely Rochard (W 17-2) | 830 | 2:07 |
| April 15, 2022 | VIRGINIA * | L | 3-5 | 3 8 0 | 5 9 1 | 7 | 31-6 | 14-2 | Emma Lemley (L 12-4) | 1024 | 2:39 |
| April 16, 2022 | VIRGINIA * | W | 5-4 | 5 12 1 | 4 9 1 | (8) | 32-6 | 15-2 | Keely Rochard (W 18-2) | 1024 | 2:49 |
| April 20, 2022 |  at (14) Tennessee | W | 5-2 | 5 5 2 | 2 7 1 | 7 | 33-6 | - | Emma Lemley (W 13-4) | 2091 | 2:32 |
| April 22, 2022 |  LOUISVILLE * | W | 4-3 | 4 9 0 | 3 8 0 | 7 | 34-6 | 16-2 | Keely Rochard (W 19-2) | 837 | 2:02 |
| April 23, 2022 | LOUISVILLE * | W | 3-0 | 3 4 0 | 0 3 0 | 7 | 35-6 | 17-2 | Emma Lemley (W 14-4) | 1024 | 2:12 |
| April 24, 2022 | LOUISVILLE * | W | 7-4 | 7 12 3 | 4 3 0 | 7 | 36-6 | 18-2 | Keely Rochard (W 20-2) | 975 | 2:20 |
| April 29, 2022 |  at Boston College * | W | 3-0 | 3 7 0 | 0 4 3 | 7 | 37-6 | 19-2 | Keely Rochard (W 21-2) | 153 | 2:23 |
| April 30, 2022 | at Boston College * | W | 9-0 | 9 10 1 | 0 3 3 | (6) | 38-6 | 20-2 | Emma Lemley (W 15-4) | 520 | 2:03 |
| May 1, 2022 | at Boston College * | W | 8-4 | 8 10 0 | 4 7 3 | 7 | 39-6 | 21-2 | Keely Rochard (W 22-2) | 305 | 2:11 |
| May 3, 2022 | LIBERTY | W | 13-9 | 13 11 1 | 9 8 1 | (6) | 40-6 | - | Ivy Rosenberry (W 2-0) | 620 | 2:22 |
| May 12, 2022 | vs Syracuse | W | 2-1 | 2 5 0 | 1 7 0 | 7 | 41-6 | - | Keely Rochard (W 23-2) | 423 | 2:23 |
| May 13, 2022 | vs Clemson | L | 1-4 | 1 4 1 | 4 5 0 | 7 | 41-7 | - | Emma Lemley (L 15-6) | 667 | 1:47 |
| May 20, 2022 |  SAINT FRANCIS | W | 4-0 | 4 8 0 | 0 0 1 | 7 | 42-7 | - | Keely Rochard (W 24-2) | 1923 | 2:01 |
| May 21, 2022 | (15) KENTUCKY | L | 4-5 | 4 5 2 | 5 10 1 | 7 | 42-8 | - | Keely Rochard (L 24-3) | 1941 | 2:18 |
| May 21, 2022 | MIAMI UNIVERSITY | W | 5-4 | 5 8 1 | 4 5 0 | 7 | 43-8 | - | Mackenzie Osborne (W 2-0) | 1224 | 2:24 |
| May 22, 2022 | (15) KENTUCKY | W | 9-2 | 9 11 0 | 2 8 0 | 7 | 44-8 | - | Emma Lemley (W 16-5) | 1961 | 2:40 |
| May 22, 2022 | (15) KENTUCKY | W | 5-4 | 5 8 1 | 4 6 0 | 7 | 45-8 | - | Keely Rochard (W 25-3) | 1961 | 2:15 |
| May 27, 2022 |  (12) FLORIDA | W | 6-0 | 6 11 0 | 0 4 0 | 7 | 46-8 | - | Keely Rochard (W 26-3) | 1961 | 2:15 |
| May 28, 2022 | at (12) Florida | L | 2-7 | 2 6 1 | 7 10 0 | 7 | 46-9 | - | Emma Lemley (L 16-6) | 1987 | 2:36 |
| May 29, 2022 | (12) FLORIDA | L | 0-12 | 0 2 3 | 12 13 1 | (5) | 46-10 | - | Keely Rochard (L 26-4) | 1987 | 1:49 |
| * - Conference Game | |||||||||||