Click on a game below to view boxscore.
| Date | Opponent | Score | R H E | R H E | Inns | Overall | ACC | Pitcher of Record | Attend | Time | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| February 12, 2006 |  at Furman | W | 8-0 | 8 13 0 | 0 0 1 | (6) | 1-0 | - | Angela Tincher (W 1-0) | 0 | 1:51 |
| February 12, 2006 | at Furman | W | 10-0 | 10 16 1 | 0 4 0 | 7 | 2-0 | - | Katie Maynard (W 1-0) | 205 | 2:16 |
| February 19, 2006 |  vs UNCG | W | 3-0 | 3 6 1 | 0 2 1 | 7 | 3-0 | - | Angela Tincher (W 2-0) | 102 | 1:54 |
| February 19, 2006 |  at Charlotte | W | 10-2 | 10 12 0 | 2 1 3 | (5) | 4-0 | - | Katie Maynard (W 2-0) | 0 | 1:23 |
| February 19, 2006 | vs UNCG | W | 9-1 | 9 17 3 | 1 2 2 | 7 | 5-0 | - | Katie Maynard (W 3-0) | 112 | 2:01 |
| February 24, 2006 |  vs Pitt | W | 4-0 | 4 6 0 | 0 3 3 | 7 | 6-0 | - | Katie Maynard (W 4-0) | 237 | 1:47 |
| February 24, 2006 |  at Coastal Carolina | W | 5-1 | 5 9 0 | 1 1 1 | 7 | 7-0 | - | Angela Tincher (W 3-0) | 237 | 1:48 |
| February 25, 2006 |  vs Minnesota | W | 6-1 | 6 8 2 | 1 3 2 | 7 | 8-0 | - | Katie Maynard (W 5-0) | 0 | 1:55 |
| February 25, 2006 | at Coastal Carolina | W | 4-0 | 4 5 0 | 0 2 3 | (5) | 9-0 | - | Angela Tincher (W 4-0) | 245 | 1:17 |
| March 1, 2006 |  RADFORD | L | 0-11 | 0 5 2 | 11 5 0 | (5) | 9-1 | - | Katie Maynard (L 5-1) | 512 | 1:16 |
| March 1, 2006 | RADFORD | W | 3-2 | 3 4 0 | 2 0 0 | (9) | 10-1 | - | Angela Tincher (W 5-0) | 0 | 1:54 |
| March 3, 2006 |  vs Portland State | L | 1-3 | 1 8 1 | 3 7 0 | 7 | 10-2 | - | Katie Maynard (L 5-2) | 0 | 1:37 |
| March 3, 2006 |  vs Nevada | W | 6-5 | 6 10 1 | 5 5 1 | (11) | 11-2 | - | Angela Tincher (W 6-0) | 316 | 2:30 |
| March 4, 2006 |  vs (12) Arizona State | W | 2-1 | 2 8 0 | 1 2 0 | (8) | 12-2 | - | Angela Tincher (W 7-0) | 0 | 2:12 |
| March 4, 2006 |  vs Southern Utah | W | 10-2 | 10 11 0 | 2 5 3 | (6) | 13-2 | - | Katie Maynard (W 6-2) | 226 | 1:46 |
| March 5, 2006 |  at UNLV | W | 2-1 | 2 7 1 | 1 3 1 | 7 | 14-2 | - | Angela Tincher (W 8-0) | 136 | 1:34 |
| March 9, 2006 |  vs Central Michigan | W | 6-3 | 6 10 0 | 3 5 5 | 7 | 15-2 | - | Katie Maynard (W 7-2) | 0 | 2:05 |
| March 9, 2006 |  vs Chattanooga | L | 0-1 | 0 5 1 | 1 3 2 | 7 | 15-3 | - | Angela Tincher (L 8-1) | 109 | 1:50 |
| March 10, 2006 |  vs Illinois | L | 4-5 | 4 10 1 | 5 9 0 | 7 | 15-4 | - | Katie Maynard (L 7-3) | 153 | 2:08 |
| March 10, 2006 | vs Coastal Carolina | L | 3-4 | 3 8 2 | 4 3 1 | 7 | 15-5 | - | Katie Maynard (L 7-4) | 109 | 1:54 |
| March 11, 2006 |  vs Fordham | W | 5-4 | 5 6 1 | 4 9 2 | 7 | 16-5 | - | Katie Maynard (W 8-4) | 189 | 2:21 |
| March 11, 2006 |  vs Northern Illinois | W | 6-3 | 6 15 0 | 3 5 3 | 7 | 17-5 | - | Katie Maynard (W 9-4) | 148 | 1:43 |
| March 12, 2006 |  vs NC State | L | 0-1 | 0 5 1 | 1 1 0 | (8) | 17-6 | - | Angela Tincher (L 8-2) | 234 | 2:00 |
| March 18, 2006 |  VIRGINIA * | W | 4-1 | 4 9 1 | 1 0 1 | 7 | 18-6 | 1-0 | Angela Tincher (W 9-2) | 0 | 1:46 |
| March 18, 2006 | VIRGINIA * | L | 3-4 | 3 4 2 | 4 5 2 | 7 | 18-7 | 1-1 | Katie Maynard (L 9-5) | 541 | 1:41 |
| March 19, 2006 | VIRGINIA * | W | 10-2 | 10 10 0 | 2 1 1 | (5) | 19-7 | 2-1 | Angela Tincher (W 10-2) | 416 | 1:41 |
| March 22, 2006 |  MARSHALL | W | 9-5 | 9 11 2 | 5 6 0 | 7 | 20-7 | - | Angela Tincher (W 11-2) | 0 | 1:59 |
| March 22, 2006 | MARSHALL | W | 12-5 | 12 12 3 | 5 4 2 | (6) | 21-7 | - | Angela Tincher (W 12-2) | 203 | 2:14 |
| March 25, 2006 | at NC State * | W | 3-2 | 3 3 1 | 2 1 0 | 7 | 22-7 | 3-1 | Angela Tincher (W 13-2) | 0 | 1:40 |
| March 25, 2006 | at NC State * | L | 0-8 | 0 2 1 | 8 8 1 | (5) | 22-8 | 3-2 | Katie Maynard (L 9-6) | 120 | 1:26 |
| March 26, 2006 | at NC State * | W | 2-1 | 2 8 0 | 1 2 1 | (9) | 23-8 | 4-2 | Angela Tincher (W 14-2) | 110 | 2:05 |
| March 28, 2006 |  SOUTH CAROLINA | W | 1-0 | 1 5 0 | 0 3 1 | 7 | 24-8 | - | Angela Tincher (W 15-2) | 0 | 1:23 |
| March 28, 2006 | SOUTH CAROLINA | W | 2-1 | 2 3 1 | 1 2 1 | (5) | 25-8 | - | Katie Maynard (W 10-6) | 218 | 1:25 |
| April 1, 2006 |  at Boston College * | W | 7-6 | 7 13 4 | 6 5 1 | 7 | 26-8 | 5-2 | Angela Tincher (W 17-2) | 0 | 2:05 |
| April 1, 2006 | at Boston College * | W | 2-0 | 2 7 0 | 0 2 0 | 7 | 27-8 | 6-2 | Angela Tincher (W 16-2) | 106 | 1:49 |
| April 2, 2006 | at Boston College * | W | 6-0 | 6 10 0 | 0 3 0 | 7 | 28-8 | 7-2 | Angela Tincher (W 18-2) | 53 | 2:10 |
| April 9, 2006 |  at Maryland * | L | 0-1 | 0 3 1 | 1 2 1 | (8) | 28-9 | 7-3 | Angela Tincher (L 18-3) | 0 | 1:55 |
| April 9, 2006 | at Maryland * | L | 1-5 | 1 8 1 | 5 5 2 | 7 | 28-10 | 7-4 | Katie Maynard (L 10-7) | 202 | 1:57 |
| April 12, 2006 |  at Ohio | W | 4-3 | 4 11 1 | 3 7 1 | 7 | 29-10 | - | Katie Maynard (W 11-7) | 0 | 1:57 |
| April 12, 2006 | at Ohio | L | 1-3 | 1 2 0 | 3 6 0 | 7 | 29-11 | - | Angela Tincher (L 18-4) | 82 | 1:32 |
| April 15, 2006 |  (23) NORTH CAROLINA * | L | 0-1 | 0 2 1 | 1 1 2 | 7 | 29-12 | 7-5 | Angela Tincher (L 18-5) | 0 | 1:38 |
| April 15, 2006 | (23) NORTH CAROLINA * | W | 3-0 | 3 6 1 | 0 3 1 | 7 | 30-12 | 8-5 | Katie Maynard (W 12-7) | 1874 | 1:56 |
| April 16, 2006 | (23) NORTH CAROLINA * | L | 0-2 | 0 4 1 | 2 5 1 | 7 | 30-13 | 8-6 | Angela Tincher (L 18-6) | 452 | 1:48 |
| April 18, 2006 |  vs East Tennessee State | W | 8-2 | 8 14 0 | 2 3 1 | 7 | 31-13 | - | Angela Tincher (W 19-6) | 408 | 1:39 |
| April 21, 2006 |  FLORIDA STATE * | W | 2-0 | 2 5 0 | 0 2 0 | 7 | 32-13 | 9-6 | Angela Tincher (W 20-6) | 415 | 1:34 |
| April 22, 2006 | FLORIDA STATE * | W | 10-2 | 10 10 3 | 2 3 1 | (5) | 33-13 | 10-6 | Angela Tincher (W 21-6) | 0 | 1:40 |
| April 22, 2006 | FLORIDA STATE * | L | 7-9 | 7 10 1 | 9 6 5 | 7 | 33-14 | 10-7 | Katie Maynard (L 12-8) | 471 | 2:09 |
| April 25, 2006 | at UNCG | W | 2-0 | 2 6 0 | 0 0 3 | 7 | 34-14 | - | Angela Tincher (W 22-6) | 0 | 1:34 |
| April 25, 2006 | at UNCG | W | 5-3 | 5 12 0 | 3 7 0 | 7 | 35-14 | - | Angela Tincher (W 23-6) | 132 | 1:52 |
| April 29, 2006 |  at Georgia Tech * | W | 4-2 | 4 11 1 | 2 5 0 | 7 | 36-14 | 11-7 | Angela Tincher (W 24-6) | 0 | 1:58 |
| April 29, 2006 | at Georgia Tech * | W | 4-1 | 4 5 0 | 1 4 2 | 7 | 37-14 | 12-7 | Katie Maynard (W 13-8) | 77 | 1:44 |
| April 30, 2006 | at Georgia Tech * | L | 2-3 | 2 6 0 | 3 3 2 | 7 | 37-15 | 12-8 | Katie Maynard (L 13-9) | 117 | 1:22 |
| May 4, 2006 |  LIBERTY | L | 5-6 | 5 10 0 | 6 9 0 | 7 | 37-16 | - | Katie Maynard (L 13-10) | 0 | 1:46 |
| May 4, 2006 | LIBERTY | L | 0-3 | 0 5 3 | 3 4 0 | 7 | 37-17 | - | Karie Morrison (L 0-1) | 408 | 1:34 |
| May 11, 2006 | vs Virginia | L | 0-3 | 0 1 1 | 3 2 1 | 7 | 37-18 | - | Angela Tincher (L 24-7) | 734 | 2:09 |
| May 11, 2006 | vs Maryland | W | 1-0 | 1 3 2 | 0 2 0 | 7 | 38-18 | - | Angela Tincher (W 25-7) | 734 | 1:44 |
| May 12, 2006 | vs (22) NC State | L | 2-7 | 2 4 1 | 7 9 0 | 7 | 38-19 | - | Angela Tincher (L 25-8) | 854 | 1:54 |
| May 19, 2006 |  vs (19) Louisville | W | 1-0 | 1 7 0 | 0 3 1 | (12) | 39-19 | - | Angela Tincher (W 26-8) | 1081 | 2:44 |
| May 20, 2006 |  at (6) Tennessee | L | 1-9 | 1 4 1 | 9 8 1 | (5) | 39-20 | - | Angela Tincher (L 25-9) | 1003 | 2:32 |
| May 20, 2006 | vs (19) Louisville | L | 1-10 | 1 4 3 | 10 10 0 | (5) | 39-21 | - | Katie Maynard (L 13-11) | 1003 | 1:16 |
 | T | - | () | 39-21-1 | - | ||||||
| * - Conference Game | |||||||||||